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Title: The conserved undecapeptide shared by thiol-activated cytolysins is involved in membrane binding.
identifier: 1478461
description:
epitope description:ECTGLAWEWWRT
antigen name:Pneumolysin
host organism:Mus musculus BALB/c
antibody name:PLY-5
aggregation:
instance of dataset
availability:
available
primaryPublications: 10526185
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1010947
landingPage: http://www.iedb.org/assay/1478461
type:
Literature
publicationVenue:
FEBS Lett
dates:
1999
study type: b cell assays
subject species: Streptococcus pneumoniae
fullName:
M D Cima-Cabal
A Darji
F J Mé
ndez
F Vá
zquez
A A Jacobs
Y Shimada
Y Ohno-Iwashita
S Weiss
J R de los Toyos
method:
biological activity
name:
The conserved undecapeptide shared by thiol-activated cytolysins is involved in membrane binding.
description:
This conserved sequence is present in thiol-activated pore-forming cytolysins produced by several species of Gram-positive bacteria.
Binding of epitope-specific mAb PLY-5 to SLO prevented the binding of SLO to sheep RBC and neutralized its hemolytic activity.

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