Efficient neutralization of foot-and-mouth disease virus by monovalent antibody binding. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Efficient neutralization of foot-and-mouth disease virus by monovalent antibody binding.

Dataset

identifier:	1478436
description:	epitope description:YTASARGDLAHL antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:SD6
aggregation:	instance of dataset
availability:	available
primaryPublications:	9371652

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1008150
landingPage:	http://www.iedb.org/assay/1478436

Publication

type:	Literature
publicationVenue:	J Virol
dates:	1997

Dimension

study type:	b cell assays
subject species:	Foot-and-mouth disease virus C-S8c1

Person

fullName:	N Verdaguer I Fita E Domingo M G Mateu

Data Type

method:	biological activity

Study

name:	Efficient neutralization of foot-and-mouth disease virus by monovalent antibody binding.
description:	The sequence of the epitope can be found in: Verdaguer et al. EMBO J. 1995 Apr 18 14(8):1690-6. [PMID: 7537661] Monovalent binding by the epitope-specific mAb to the virus is sufficient for neutralization; Fab and Fab2 fragments also neutralized the virus. In another assay, the mAb inhibited the attachment of the virus to BHK-21 cells.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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