The conserved undecapeptide shared by thiol-activated cytolysins is involved in membrane binding.

Title:

The conserved undecapeptide shared by thiol-activated cytolysins is involved in membrane binding.

identifier:	1478454
description:	epitope description:ECTGLAWEWWRT antigen name:Pneumolysin host organism:Mus musculus BALB/c antibody name:PLY-5
aggregation:	instance of dataset
availability:	available
primaryPublications:	10526185

study type:	b cell assays
subject species:	Streptococcus pneumoniae

fullName:	M D Cima-Cabal A Darji F J Mé ndez F Vá zquez A A Jacobs Y Shimada Y Ohno-Iwashita S Weiss J R de los Toyos

method:	antigen inhibition

name:	The conserved undecapeptide shared by thiol-activated cytolysins is involved in membrane binding.
description:	This conserved sequence is present in thiol-activated pore-forming cytolysins produced by several species of Gram-positive bacteria. The epitope sequence was deduced through study of overlapping peptides. The region of overlap indicated the core sequence to be WEWWRT. The epitope blocked the ability of mAb PLY-5 to neutralize the hemolytic activity of PLY. The epitope corresponds to the conserved undecapeptide shared by thiol-activated cytolysins.

name:	iedb
homePage:	http://www.iedb.org

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