Bactericidal antibody recognition of a PorA epitope of Neisseria meningitidis: crystal structure of a Fab fragment in complex with a fluorescein-conjugated peptide.

Title:

Bactericidal antibody recognition of a PorA epitope of Neisseria meningitidis: crystal structure of a Fab fragment in complex with a fluorescein-conjugated peptide.

Dataset

identifier:	1480185
description:	epitope description:TKDTNNNL + ACET(T1) antigen name:Major outer membrane protein P.IA host organism:Mus musculus antibody name:MN12H2
aggregation:	instance of dataset
availability:	available
primaryPublications:	9294871

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1009114
landingPage:	http://www.iedb.org/assay/1480185

Publication

type:	Literature
publicationVenue:	Proteins
dates:	1997

Dimension

study type:	b cell assays
subject species:	Neisseria meningitidis serogroup B H44/76

Person

fullName:	J M van den Elsen J N Herron P Hoogerhout J T Poolman E Boel T Logtenberg J Wilting D J Crommelin J Kroon P Gros

Data Type

method:	x-ray crystallography

Study

name:	Bactericidal antibody recognition of a PorA epitope of Neisseria meningitidis: crystal structure of a Fab fragment in complex with a fluorescein-conjugated peptide.
description:	The peptide was synthesized with a C-terminal S-(4-fluoresceinylcarbamoylmethyl)-cysteinyl residue and C-terminally amidated. In the antigen, the C-terminus is an added Cys-fluorescein conjugated moiety (S-(4-fluoresceinylcarbamoylmethyl)-cysteinyl).

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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