Antibody responses are generated to immunodominant ELK/KLE-type motifs on the nonstructural-1 glycoprotein during live dengue virus infections in mice and humans: implications for diagnosis, pathogenesis, and vaccine design.

Title:

Dataset

identifier:	1480262
description:	epitope description:YSWKTWG antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:3D1.4, 4H3.4, 3A5.4
aggregation:	instance of dataset
availability:	available
primaryPublications:	17329445

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1006742
landingPage:	http://www.iedb.org/assay/1480262

Publication

type:	Literature
publicationVenue:	Clin Vaccine Immunol
dates:	2007

Dimension

study type:	b cell assays
subject species:	Dengue virus 2 Puerto Rico/PR159-S1/1969

Person

fullName:	Andrew K I Falconar

Data Type

method:	ELISA

Study

name:	Antibody responses are generated to immunodominant ELK/KLE-type motifs on the nonstructural-1 glycoprotein during live dengue virus infections in mice and humans: implications for diagnosis, pathogenesis, and vaccine design.
description:	This epitope sequence is conserved in NS1 of Dengue type 3 and type 4 virus. The epitope of mAbs 3D1.4, 4H3.4, 3A5.4 was determined through study of overlapping peptides spanning residues 105-129 of D-2V (strains PR159S1 and TR1751) NS1 and sequential truncations of the peptide LRYSWKTWG.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.