Location and primary structure of a major antigenic site for poliovirus neutralization. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Location and primary structure of a major antigenic site for poliovirus neutralization.

Dataset

identifier:	1480426
description:	epitope description:R98 antigen name:Genome polyprotein host organism:Rattus norvegicus antibody name:25-1-14, 25-4-12, 25-5-5, 27-4-4
aggregation:	instance of dataset
availability:	available
primaryPublications:	6186919

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1011523
landingPage:	http://www.iedb.org/assay/1480426

Publication

type:	Literature
publicationVenue:	Nature
dates:	1983

Dimension

study type:	b cell assays
subject species:	Human poliovirus 3

Person

fullName:	P D Minor G C Schild J Bootman D M Evans M Ferguson P Reeve M Spitz G Stanway A J Cann R Hauptmann L D Clarke R C Mountford J W Almond

Data Type

method:	biological activity

Study

name:	Location and primary structure of a major antigenic site for poliovirus neutralization.
description:	The epitopic residue is conserved in VP1 from multiple strains of poliovirus type 3. VP1 residue Thr96 was determined to be a critical residue recognized by the neutralizing mAbs 25-1-14, 25-4-12, 25-5-5, and 27-4-4, that recognize different epitopes within the same antigenic site. Antibody-resistant mutants, isolated from Leon 970 type 3 poliovirus after 2 cycles of selection with neutralizing mAbs, had an Arg to Gln substitution at residue 98.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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