Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoprotein.

Title:

Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoprotein.

Dataset

identifier:	1480500
description:	epitope description:S275 antigen name:Fusion glycoprotein F0 host organism:Mus musculus antibody name:1129
aggregation:	instance of dataset
availability:	available
primaryPublications:	9878616

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1011691
landingPage:	http://www.iedb.org/assay/1480500

Publication

type:	Literature
publicationVenue:	Virology
dates:	1998

Dimension

study type:	b cell assays
subject species:	Human respiratory syncytial virus A2

Person

fullName:	J E Crowe C Y Firestone R Crim J A Beeler K L Coelingh C F Barbas D R Burton R M Chanock B R Murphy

Data Type

method:	biological activity

Study

name:	Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoprotein.
description:	Antibody escape mutants were used to identify the RSV F glycoprotein amino acid critical for binding of the murine RSV F-neutralizing mAb.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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