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Title: Cyclic disulfide model of the major antigenic site of serotype-C foot-and-mouth disease virus. Synthetic, conformational and immunochemical studies.
identifier: 1480802
description:
epitope description:TTCTASARGDLAHLTTTHACHL
host organism:Mus musculus
antibody name:SD6, 4C4, 5A2, 6D11, 7FC12, 7AH1, 7CA11
aggregation:
instance of dataset
availability:
available
primaryPublications: 7688321
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1008778
landingPage: http://www.iedb.org/assay/1480802
type:
Literature
publicationVenue:
FEBS Lett
dates:
1993
study type: b cell assays
subject species:
fullName:
J A Camarero
D Andreu
J J Cairó
M G Mateu
E Domingo
E Giralt
method:
antigen inhibition
name:
Cyclic disulfide model of the major antigenic site of serotype-C foot-and-mouth disease virus. Synthetic, conformational and immunochemical studies.
description:
The epitope is an analog of FMDV VP1 (134-155) with Y136 and R153 replaced by Cys residues to allow cyclization of the peptide.
The epitope, in either a linear or cyclic form, inhibited the binding of mAbs SD6, 4C4, 5A2, 6D11, 7FC12, 7AH1, or 7CA11 to immobilized linear epitope coupled to KLH. The mAbs recognize different epitopes within antigenic site A on the VP1 G-H loop of FMDV serotype C.

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