Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein.

Title:

Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein.

Dataset

identifier:	1480916
description:	epitope description:DLAHLTA antigen name:Polyprotein host organism:Oryctolagus cuniculus antibody name:anti-VP1 Peptide C₁
aggregation:	instance of dataset
availability:	available
primaryPublications:	2578661

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1008339
landingPage:	http://www.iedb.org/assay/1480916

Publication

type:	Literature
publicationVenue:	Proc Natl Acad Sci U S A
dates:	1985

Dimension

study type:	b cell assays
subject species:	Foot-and-mouth disease virus C1

Person

fullName:	H M Geysen S J Barteling R H Meloen

Data Type

method:	ELISA

Study

name:	Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein.
description:	The epitope was synthesized with an N-terminal Cys and a C-terminal Lys residue. Sera from rabbits immunized with the epitope exhibited 49% cross-reaction with the homologous peptide from FMDV type A₁₀ VP1 (GDLGSIA), which was synthesized with an N-terminal Cys and a C-terminal Lys residue.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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