Peptide mimotopes as prototypic templates of broad-spectrum surrogates of carbohydrate antigens. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Peptide mimotopes as prototypic templates of broad-spectrum surrogates of carbohydrate antigens.

Dataset

identifier:	1483038
description:	epitope description:GGIYYPYDIYYPYDIYYPYD host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	12887105

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1012089
landingPage:	http://www.iedb.org/assay/1483038

Publication

type:	Literature
publicationVenue:	Cell Mol Biol (Noisy-le-grand)
dates:	2003

Dimension

study type:	b cell assays
subject species:

Person

fullName:	G Cunto-Amesty P Luo B Monzavi-Karbassi A Lees J Alexander M F del Guercio M H Nahm C Artaud J Stanley

Data Type

method:	ELISA

Study

name:	Peptide mimotopes as prototypic templates of broad-spectrum surrogates of carbohydrate antigens.
description:	The anti-peptide reacted with pneumococcal capsular polysaccharide antigens prensent in the 23-valent vaccine and with Pn serotype 25. Multiple immunization protocols were tested and titers were determined at either 7 weeks after priming or one week after boosting. The highest level of IgG3 resulted from two doses of peptide conjugated to BSA. Priming with BSA-conjugated peptide and boosting with pneumococcal capsular polysaccharide type 14 (Pn14) produced higher levels of Pn14-reactive IgG1, IgG2a, IgG2b, IgG3 than priming and boosting with Pn14.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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