Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1011512 |
| landingPage: |
http://www.iedb.org/assay/1483232 |
| type: |
Literature
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| publicationVenue: |
Vaccine
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| dates: |
1990
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| study type: | b cell assays |
| subject species: | Human poliovirus 1 Mahoney |
| fullName: |
S van der Werf
A Charbit
C Leclerc
V Mimic
J Ronco
M Girard
M Hofnung
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| method: |
biological activity
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| name: |
Critical role of neighbouring sequences on the immunogenicity of the C3 poliovirus neutralization epitope expressed at the surface of recombinant bacteria.
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| description: |
Serum from 1 of 4 rabbits immunized with bacteria expressing the epitope inserted into LamB at position 153 neutralized the virus, but the anti-viral activity decreased in later bleeds. Sera from two rabbits immunoprecipitated native virions and showed stable activity over several weeks' bleeds. These rabbits had high titers toward heat-treated virus (C particles) in the preimmune sera. Sera from the two other rabbits immunoprecipitated the native virions as well as heat-treated virus (C particles), but the activity was transient .
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
