A large-scale evaluation of peptide vaccines against foot-and-mouth disease: lack of solid protection in cattle and isolation of escape mutants.

Title:

A large-scale evaluation of peptide vaccines against foot-and-mouth disease: lack of solid protection in cattle and isolation of escape mutants.

identifier:	1481370
description:	epitope description:ETQTQRRHHTDVAFVLDRFVAGARRGDLAHLAAAHARHLP host organism:Bos taurus Friesian
aggregation:	instance of dataset
availability:	available
primaryPublications:	9060612

study type:	b cell assays
subject species:

fullName:	O C E Carrillo J I Nú ñ ez A Rodrí guez J C Saí z E Blanco M L Valero X Roig J A Camarero D Andreu M G Mateu E Giralt E Domingo F Sobrino E L Palma

method:	biological activity

name:	A large-scale evaluation of peptide vaccines against foot-and-mouth disease: lack of solid protection in cattle and isolation of escape mutants.
description:	The epitope was derived from different preparations from FMDV strain C3 Arg85 with fusion of T cell epitope (residues 21-40: ETQTQRRHHTDVAFVLDRFV) and B cell epitope (residues 138-156: AGARRGDLAHLAAAHARHLP) of VP1. Cys residue was added at C-terminus. Serum neutralizing (SN) titers were determined by a plaque reduction test, as well as 50% mouse protection dose (MPD₅₀). Similar results were observed from animals immunized with various doses and schedules. Higher SN titers were associated with protection of virus challenge.

name:	iedb
homePage:	http://www.iedb.org

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