A large-scale evaluation of peptide vaccines against foot-and-mouth disease: lack of solid protection in cattle and isolation of escape mutants.

Title:

A large-scale evaluation of peptide vaccines against foot-and-mouth disease: lack of solid protection in cattle and isolation of escape mutants.

identifier:	1481317
description:	epitope description:AGVRRGDLAHLAAAHARHLP antigen name:Polyprotein host organism:Bos taurus Hereford
aggregation:	instance of dataset
availability:	available
primaryPublications:	9060612

study type:	b cell assays
subject species:	Foot-and-mouth disease virus C3

fullName:	O C E Carrillo J I Nú ñ ez A Rodrí guez J C Saí z E Blanco M L Valero X Roig J A Camarero D Andreu M G Mateu E Giralt E Domingo F Sobrino E L Palma

method:	biological activity

name:	A large-scale evaluation of peptide vaccines against foot-and-mouth disease: lack of solid protection in cattle and isolation of escape mutants.
description:	The epitope was derived from VP1 of different preparations of FMDV strain C3 Arg85. Cys residue was added at C-terminus. Serum neutralizing (SN) titers were determined by a plaque reduction test, as well as 50% mouse protection dose (MPD₅₀). Similar results were observed from animals immunized with various doses and schedules. Significantly higher FMDV-specific IgG1/IgG2 ratios were observed. Higher SN titers were associated with protection of virus challenge.

name:	iedb
homePage:	http://www.iedb.org

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