Molecular basis for linkage of a continuous and discontinuous neutralization epitope on the structural polypeptide VP2 of poliovirus type 1.

Title:

Molecular basis for linkage of a continuous and discontinuous neutralization epitope on the structural polypeptide VP2 of poliovirus type 1.

identifier:	1482258
description:	epitope description:H142, N165, N166, T168 antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:27.108
aggregation:	instance of dataset
availability:	available
primaryPublications:	1689392

study type:	b cell assays
subject species:	Human poliovirus 1 Mahoney

fullName:	K J Wiegers K Wetz R Dernick

method:	biological activity

name:	Molecular basis for linkage of a continuous and discontinuous neutralization epitope on the structural polypeptide VP2 of poliovirus type 1.
description:	MAb 27.108, which recognized the epitopic residues, neutralized the virus. Antibody-resistant variants selected in the presence of mAb 27.108 showed that residues N165, N166, T168 and H142 in an adjacent loop of a double-loop structure are important for recognition.

name:	iedb
homePage:	http://www.iedb.org

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