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Title: Protection of guinea-pigs against foot-and-mouth disease virus by immunization with a PhoE-FMDV hybrid protein.
identifier: 1482242
description:
epitope description:YKQKIIAPYKQKIIAPSRRGDLGSLAPRV
host organism:Cavia porcellus Duncan-Hartley
aggregation:
instance of dataset
availability:
available
primaryPublications: 2174595
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1006807
landingPage: http://www.iedb.org/assay/1482242
type:
Literature
publicationVenue:
Vaccine
dates:
1990
study type: b cell assays
subject species:
fullName:
M Agterberg
H Adriaanse
S Barteling
K van Maanen
J Tommassen
method:
biological activity
name:
Protection of guinea-pigs against foot-and-mouth disease virus by immunization with a PhoE-FMDV hybrid protein.
description:
This synthetic peptide contains two antigenic determinants of the structural protein VP1 of foot-and-mouth disease virus type A10. These include two tandem repeats of the VP1 200-207 epitope (YKQKIIAP) previously shown to be recognized by monoclonal antibody MA18, as well as the VP1 141-153 epitope (SRRGDLGSLAPRV) previously shown to be recognized by monoclonal antibody MA 11.
Virus-neutralizing antibodies were detected in the sera of animals after immunization with the hybrid protein containing FMDV epitopes.

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