Characterization of monoclonal antibodies against a type SAT 2 foot-and-mouth disease virus. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Characterization of monoclonal antibodies against a type SAT 2 foot-and-mouth disease virus.

Dataset

identifier:	1482959
description:	epitope description:V610 antigen name:Polyprotein host organism:Mus musculus antibody name:MAbs 2, 40, 27, 37
aggregation:	instance of dataset
availability:	available
primaryPublications:	7691630

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1011502
landingPage:	http://www.iedb.org/assay/1482959

Publication

type:	Literature
publicationVenue:	Epidemiol Infect
dates:	1993

Dimension

study type:	b cell assays
subject species:	Foot-and-mouth disease virus - type SAT 2 (strain Rho 1/48)

Person

fullName:	J R Crowther C A Rowe R Butcher

Data Type

method:	biological activity

Study

name:	Characterization of monoclonal antibodies against a type SAT 2 foot-and-mouth disease virus.
description:	Critical residue for mAb binding was identified with escape mutants and various FMDV SAT2 isolates. Mutation or change at the residue eliminated the neutralization. Similar results were observed in haemagglutination inhibition assay. Each mAb bound differently to various isolates/strains.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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