Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1008295 |
| landingPage: |
http://www.iedb.org/assay/1485998 |
| type: |
Literature
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| publicationVenue: |
Cell Immunol
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| dates: |
1990
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| study type: | b cell assays |
| subject species: | Respiratory syncytial virus |
| fullName: |
M E Levely
M A Mitchell
J A Nicholas
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| method: |
antigen inhibition
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| name: |
Synthetic immunogens constructed from T-cell and B-cell stimulating peptides (T:B chimeras): preferential stimulation of unique T- and B-cell specificities is influenced by immunogen configuration.
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| description: |
The epitope inhibited the binding of anti-epitope serum to the epitope. The greatest inhibition of binding was seen with the construct composed of RSV G protein 151-164 chemically crosslinked to the epitope (G-BMH-1A). Anti-serum from mice immunized with the epitope alone or with one of the constructs also bound the epitope alone or one of the constructs by ELISA. The constructs tested as antigen were the following: linear construct of the epitope conjugated to RSV G protein 151-164 with GG in between (1A-Gly2-G), RSV G protein 151-164 chemically crosslinked to the epitope (G-BMH-1A), or a linear construct of the epitope conjugated to RSV F protein 221-236 with GG in between (1A-Gly2-F).
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
