Intrinsic immunogenicity of an internal VP1 T-B epitope pair of type 1 poliovirus. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Intrinsic immunogenicity of an internal VP1 T-B epitope pair of type 1 poliovirus.

Dataset

identifier:	1483500
description:	epitope description:RSRSESSIESF antigen name:Genome polyprotein host organism:Mus musculus SJL antibody name:anti-VP1 (70-80)
aggregation:	instance of dataset
availability:	available
primaryPublications:	1280759

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1008241
landingPage:	http://www.iedb.org/assay/1483500

Publication

type:	Literature
publicationVenue:	Mol Immunol
dates:	1992

Dimension

study type:	b cell assays
subject species:	Human poliovirus 1

Person

fullName:	G K Lewis C P Feng

Data Type

method:	ELISA

Study

name:	Intrinsic immunogenicity of an internal VP1 T-B epitope pair of type 1 poliovirus.
description:	Sera from LP/J or SJL mice immunized and boosted with the epitope in Freund's adjuvant did not show a significant secondary antibody response to the epitope. Sera from immunized BALB/c, A/J, CBA/N or C57BL/6 mice did respond. The authors conclude that the epitope harbors a T and B cell epitope and the response is under genetic control where mice of the H-2k, H-2b, H-2a or H-2d haplotype are responders and H-2s and H-2 q are poor responders.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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