The molecular basis of virus crossreactivity and neutralisation after immunisation with optimised chimeric peptides mimicking a putative helical epitope of the measles virus hemagglutinin protein.

Title:

The molecular basis of virus crossreactivity and neutralisation after immunisation with optimised chimeric peptides mimicking a putative helical epitope of the measles virus hemagglutinin protein.

Dataset

identifier:	1484090
description:	epitope description:KPNLSSKRSELSQLSMYRVF antigen name:Hemagglutinin glycoprotein host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	9881686

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1010186
landingPage:	http://www.iedb.org/assay/1484090

Publication

type:	Literature
publicationVenue:	Mol Immunol
dates:	1998

Dimension

study type:	b cell assays
subject species:	Measles virus strain Edmonston

Person

fullName:	K C El Kasmi D Theisen N H Brons C P Muller

Data Type

method:	surface plasmon resonance (SPR)

Study

name:	The molecular basis of virus crossreactivity and neutralisation after immunisation with optimised chimeric peptides mimicking a putative helical epitope of the measles virus hemagglutinin protein.
description:	TB chimeras containing the MV F421-435 T helper epitope (TCE) linked to the B cell epitope (BCE) MV H236-255 generated anti-peptide antibodies, as well as anti-measles virus antibodies. The association curve of the neutralizing serum induced with the epitope was indicative of high affinity compared to other constructs.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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