Rational dissection of binding surfaces for mimicking of discontinuous antigenic sites. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Rational dissection of binding surfaces for mimicking of discontinuous antigenic sites.

Dataset

identifier:	1484206
description:	epitope description:CTGDKENVYPSQNFGHMHKSEKDRGC host organism:Cavia porcellus Duncan-Hartley
aggregation:	instance of dataset
availability:	available
primaryPublications:	16931331

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1006061
landingPage:	http://www.iedb.org/assay/1484206

Publication

type:	Literature
publicationVenue:	Chem Biol
dates:	2006

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Judit Villé n Ricard A Rodrí guez-Mias José I Nú ñ ez Ernest Giralt Francisco Sobrino David Andreu

Data Type

method:	biological activity

Study

name:	Rational dissection of binding surfaces for mimicking of discontinuous antigenic sites.
description:	The epitope is a construct of sequences from FMDV that form loop structures and comprise an antigenic site, including VP1 (193-195, TGD), VP3 (K84), VP3 (58-60, ENV), VP3 (Y63), VP2 (72-80,PSQNFGHMHK), and a VP2 analog (133-137, SEKDR). Sera from guinea pigs immunized with the cyclic epitope, or the cyclic peptide with an insertion of a 6-aminohexanoic acid residue instead of Gly next to the C-terminal Cys, neutralized viral infectivity in cells. Sera from guinea pigs immunized with the cyclic epitope modified by insertion of a 6-aminohexanoic acid or beta-Ala residue next to the N-terminal Cys, were less effective at virus neutralization.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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