Analysis of immune responses in the sheep to synthetic peptides of foot-and-mouth disease virus using ovine polyclonal and monoclonal antibodies.

Title:

Analysis of immune responses in the sheep to synthetic peptides of foot-and-mouth disease virus using ovine polyclonal and monoclonal antibodies.

identifier:	1484517
description:	epitope description:VPNLRGDLQVLAQKVART antigen name:Genome polyprotein host organism:Ovis aries
aggregation:	instance of dataset
availability:	available
primaryPublications:	1690176

study type:	b cell assays
subject species:	Foot-and-mouth disease virus (strain O1) Kaufbeuren

fullName:	J N Flynn G D Harkiss R DiMarchi

method:	antigen inhibition

name:	Analysis of immune responses in the sheep to synthetic peptides of foot-and-mouth disease virus using ovine polyclonal and monoclonal antibodies.
description:	The epitope was synthesized with Pro-Cys-Gly added to the C-terminus. The epitope sequence is from reference cited: DiMarchi et al. (1986) Science. 232: 639-641. [PMID: 3008333] Sera from sheep immunized with the epitope bound to a 40-residue peptide (CCRHKQKIVAPVKQTLPPSVPNLRGDLQVLAQKVARTPCG), which contained the epitope. The 40-residue peptide inhibited the anti-21-residue peptide antisera from binding to the epitope or to the 40-residue peptide.

name:	iedb
homePage:	http://www.iedb.org

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