Analysis of immune responses in the sheep to synthetic peptides of foot-and-mouth disease virus using ovine polyclonal and monoclonal antibodies.

Title:

Analysis of immune responses in the sheep to synthetic peptides of foot-and-mouth disease virus using ovine polyclonal and monoclonal antibodies.

identifier:	1484539
description:	epitope description:CCRHKQKIVAPVKQTLPPSVPNLRGDLQVLAQKVARTPCG host organism:Ovis aries
aggregation:	instance of dataset
availability:	available
primaryPublications:	1690176

study type:	b cell assays
subject species:

fullName:	J N Flynn G D Harkiss R DiMarchi

method:	in vivo assay

name:	Analysis of immune responses in the sheep to synthetic peptides of foot-and-mouth disease virus using ovine polyclonal and monoclonal antibodies.
description:	The epitope is a construct of FMDV VP1 residues 200-213 joined by a Pro-Pro-Ser linker to residues 141-158 and with a dicysteine at the N-terminus and Pro-Cys-Gly at the C-terminus. The epitope sequence is from reference cited: DiMarchi et al. (1986) Science. 232: 639-641. [PMID: 3008333] Passively transferred sera from sheep immunized with the epitope conferred protective immunity in a mouse protection assay.

name:	iedb
homePage:	http://www.iedb.org

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