Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1006612 |
| landingPage: |
http://www.iedb.org/assay/1484559 |
| type: |
Literature
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| publicationVenue: |
Vaccine
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| dates: |
1999
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| study type: | b cell assays |
| subject species: | Measles virus strain Edmonston |
| fullName: |
K C El Kasmi
D Theisen
N H Brons
W Ammerlaan
M Klingele
A T Truong
C P Muller
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| method: |
ELISA
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| name: |
A hemagglutinin-derived peptide-vaccine ignored by virus-neutralizing passive antibodies, protects against murine measles encephalitis.
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| description: |
Adult mice were injected (passive immunization) with protecitve levels of anti-MV (Edmonston strain) antibodies. Within one hour these mice were actively immunized with a TTB chimera consisting of two copiees of the MV F421-435 T cell epitope and one copy of the MV H236-250 peptide (containig the minimal B cell epitope). The chimera induced B cell epitope-specific antibodies (BCE H236-250) showing that the vaccine construct can generate specific antibodies in the presence of pre-existing passive or maternal antibodies.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
