Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1012228 |
| landingPage: |
http://www.iedb.org/assay/1484616 |
| type: |
Literature
|
| publicationVenue: |
Hum Vaccin
|
| dates: |
2006
|
| study type: | b cell assays |
| subject species: | Plasmodium falciparum |
| fullName: |
Zhiyong Zhou
Charles W Todd
Robert M Wohlhueter
April Price
Lihua Xiao
Paul Schnake
Phillip Cullison Bonner
Amy M Martin
Ira F Goldman
Patricia De La Vega
Venkatachalam Udhayakumar
Altaf A Lal
|
| method: |
ELISA
|
| name: |
Development, characterization and immunogenicity of a multi-stage, multi-valent Plasmodium falciparum vaccine antigen (FALVAC-1A) expressed in Escherichia coli.
|
| description: |
Rabbits immunized with the multi-epitope vaccine construct FALVAC-1A were tested for reactivity against individual epitopes. While high titers were achieved with all adjuvants tested, the water-in-oil emulsion and Montanide ISA-720 generated the highest titers. Sera from FALVAC-1A vaccinated animals were also shown to inhibit sporozoite invasion, recognized sporozoites and blood stage parasites in IFA from both Pf NF54 and FC27 strains, and demonstrated antibody-dependent cellular inhibition of Pf FC27.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
