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Title: Development, characterization and immunogenicity of a multi-stage, multi-valent Plasmodium falciparum vaccine antigen (FALVAC-1A) expressed in Escherichia coli.
identifier: 1484630
description:
epitope description:SSPSSTKSSSPSNVKSAS
antigen name:Rhoptry-associated protein 1, RAP1
host organism:Oryctolagus cuniculus New Zealand White
antibody name:Rabbit Sera
aggregation:
instance of dataset
availability:
available
primaryPublications: 17012909
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1012228
landingPage: http://www.iedb.org/assay/1484630
type:
Literature
publicationVenue:
Hum Vaccin
dates:
2006
study type: b cell assays
subject species: Plasmodium falciparum
fullName:
Zhiyong Zhou
Charles W Todd
Robert M Wohlhueter
April Price
Lihua Xiao
Paul Schnake
Phillip Cullison Bonner
Amy M Martin
Ira F Goldman
Patricia De La Vega
Venkatachalam Udhayakumar
Altaf A Lal
method:
ELISA
name:
Development, characterization and immunogenicity of a multi-stage, multi-valent Plasmodium falciparum vaccine antigen (FALVAC-1A) expressed in Escherichia coli.
description:
Rabbits immunized with the multi-epitope vaccine construct FALVAC-1A were tested for reactivity against individual epitopes. While high titers were achieved with all adjuvants tested, the water-in-oil emulsion and Montanide ISA-720 generated the highest titers. Sera from FALVAC-1A vaccinated animals were also shown to inhibit sporozoite invasion, recognized sporozoites and blood stage parasites in IFA from both Pf NF54 and FC27 strains, and demonstrated antibody-dependent cellular inhibition of Pf FC27.

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