Use of monoclonal antibodies to identify four neutralization immunogens on a common cold picornavirus, human rhinovirus 14.

Title:

Use of monoclonal antibodies to identify four neutralization immunogens on a common cold picornavirus, human rhinovirus 14.

identifier:	1487659
description:	epitope description:D658, E662 antigen name:Genome polyprotein host organism:Mus musculus antibody name:17, 27, 34, 11, 15, 19, 23, 12, 14, 20
aggregation:	instance of dataset
availability:	available
primaryPublications:	2416951

study type:	b cell assays
subject species:	Rhinovirus B14

fullName:	B Sherry A G Mosser R J Colonno R R Rueckert

method:	biological activity

name:	Use of monoclonal antibodies to identify four neutralization immunogens on a common cold picornavirus, human rhinovirus 14.
description:	The sequence is from the reference cited: Stanway et al.(1984) Nuc Acids Res 12: 7859-7875 [PMID: 6093056]. The epitopic residues in the NIm-IA antigenic site recognized by the mAbs was determined by sequencing variant viruses selected with the mAbs. Variants with mutation of VP1 residue Asp91 to a Glu, His, Ala, Tyr, Val, Asn, or Gly or mutation of residue Glu95 to a Lys or Gly were not neutralized by the mAbs.

name:	iedb
homePage:	http://www.iedb.org

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