Epitope determinants of a chimpanzee dengue virus type 4 (DENV-4)-neutralizing antibody and protection against DENV-4 challenge in mice and rhesus monkeys by passively transferred humanized antibody.

Title:

Epitope determinants of a chimpanzee dengue virus type 4 (DENV-4)-neutralizing antibody and protection against DENV-4 challenge in mice and rhesus monkeys by passively transferred humanized antibody.

Dataset

identifier:	1488482
description:	epitope description:K174, P176 antigen name:Genome polyprotein host organism:Pan troglodytes
aggregation:	instance of dataset
availability:	available
primaryPublications:	17881450

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1007632
landingPage:	http://www.iedb.org/assay/1488482

Publication

type:	Literature
publicationVenue:	J Virol
dates:	2007

Dimension

study type:	b cell assays
subject species:	Dengue virus 4 Dominica/814669/1981

Person

fullName:	Ching-Juh Lai Ana P Goncalvez Ruhe Men Claire Wernly Olivia Donau Ronald E Engle Robert H Purcell

Data Type

method:	in vivo assay

Study

name:	Epitope determinants of a chimpanzee dengue virus type 4 (DENV-4)-neutralizing antibody and protection against DENV-4 challenge in mice and rhesus monkeys by passively transferred humanized antibody.
description:	Passive transfer of IgG 5H2 delta D antibodies protected rhesus monkeys from DENV-4 infection. Viremia was not detected in any of the four animals that received the transfered. In a separate assay, the onset of viremia was shown to be delayed and its duration shorted following passive transfer of the epitope-specific antibody [Men et al. J Virol 2004;78:4665 (PMID: 15078949)].

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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