The neutralizing antibody response against West Nile virus in naturally infected horses. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

The neutralizing antibody response against West Nile virus in naturally infected horses.

Dataset

identifier:	1488681
description:	epitope description:S306, K307, T330, T332 antigen name:Genome polyprotein host organism:Equus caballus antibody name:Horse sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	17055550

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1003567
landingPage:	http://www.iedb.org/assay/1488681

Publication

type:	Literature
publicationVenue:	Virology
dates:	2007

Dimension

study type:	b cell assays
subject species:	West Nile virus NY-99

Person

fullName:	Melissa D Sá nchez Theodore C Pierson Marciela M Degrace Lisa M Mattei Sheri L Hanna Fabio Del Piero Robert W Doms

Data Type

method:	biological activity

Study

name:	The neutralizing antibody response against West Nile virus in naturally infected horses.
description:	Horses with high WNV ELISA titers efficiently blocked binding of neutralizing MAbs 8B10 and 11C2 to sub-viral particles. These results indicated that the T332 neutralizing epitope is a target of the humoral immune response during natural infection of WNV in horses. For some sera, neutralization of sub-virus particles was abrogated when the epitope residues were mutated, suggesting that some but not all infected animals, antibodies that bind to the DIII epitope that includes residues 306, 307, 330 and 332 comprise a significant fraction of total neutralizing activity.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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