Humanized monoclonal antibodies derived from chimpanzee Fabs protect against Japanese encephalitis virus in vitro and in vivo.

Title:

Humanized monoclonal antibodies derived from chimpanzee Fabs protect against Japanese encephalitis virus in vitro and in vivo.

identifier:	1489873
description:	epitope description:I126 antigen name:Genome polyprotein host organism:Pan troglodytes antibody name:B2
aggregation:	instance of dataset
availability:	available
primaryPublications:	18480437

study type:	b cell assays
subject species:	Japanese encephalitis virus

fullName:	Ana P Goncalvez Cheng-Hsin Chien Kamolchanok Tubthong Inna Gorshkova Carrie Roll Olivia Donau Peter Schuck Sutee Yoksan Sy-Dar Wang Robert H Purcell Ching-Juh Lai

method:	immunoprecipitation

name:	Humanized monoclonal antibodies derived from chimpanzee Fabs protect against Japanese encephalitis virus in vitro and in vivo.
description:	The humanized mAbs A3 and E3 bound recombinant JEV E protein under reducing and non-reducing conditions, whereas mAb B2 bound the recombinant antigen only under non-reducing conditions. In a separate assay, mutant E proteins (single substitutions at positions 126, 179 and 302) were used to identify critical binding residues.

name:	iedb
homePage:	http://www.iedb.org

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