Humanized monoclonal antibodies derived from chimpanzee Fabs protect against Japanese encephalitis virus in vitro and in vivo.

Title:

Humanized monoclonal antibodies derived from chimpanzee Fabs protect against Japanese encephalitis virus in vitro and in vivo.

identifier:	1489882
description:	epitope description:I126 antigen name:Genome polyprotein host organism:Pan troglodytes antibody name:B2
aggregation:	instance of dataset
availability:	available
primaryPublications:	18480437

study type:	b cell assays
subject species:	Japanese encephalitis virus

fullName:	Ana P Goncalvez Cheng-Hsin Chien Kamolchanok Tubthong Inna Gorshkova Carrie Roll Olivia Donau Peter Schuck Sutee Yoksan Sy-Dar Wang Robert H Purcell Ching-Juh Lai

method:	biological activity

name:	Humanized monoclonal antibodies derived from chimpanzee Fabs protect against Japanese encephalitis virus in vitro and in vivo.
description:	The Fab B2 demonstrated JEV-neutralizing activity (genotype III). This Fab was also shown to neutralize other JEV genotypes to a greater extent than Fabs A3 and E3: JE1991 (I), JE B1034/8 (II), Beijing (III) and 9092 (IV).

name:	iedb
homePage:	http://www.iedb.org

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