Humanized monoclonal antibodies derived from chimpanzee Fabs protect against Japanese encephalitis virus in vitro and in vivo.

Title:

Humanized monoclonal antibodies derived from chimpanzee Fabs protect against Japanese encephalitis virus in vitro and in vivo.

identifier:	1489867
description:	epitope description:G302 antigen name:Genome polyprotein host organism:Pan troglodytes antibody name:E3
aggregation:	instance of dataset
availability:	available
primaryPublications:	18480437

study type:	b cell assays
subject species:	Japanese encephalitis virus

fullName:	Ana P Goncalvez Cheng-Hsin Chien Kamolchanok Tubthong Inna Gorshkova Carrie Roll Olivia Donau Peter Schuck Sutee Yoksan Sy-Dar Wang Robert H Purcell Ching-Juh Lai

method:	ELISA

name:	Humanized monoclonal antibodies derived from chimpanzee Fabs protect against Japanese encephalitis virus in vitro and in vivo.
description:	Fab were tested in both competitive and non-competitive ELISA for binding to JEV. Binding was detected to JEV, but not to DENV1, DENV2, DENV3, DENV4, WNV or LGTV. Binding competition was not detected among the Fabs nor with Fab 1A5, a broadly flavivirus-reactive antibody that recognizes a conserved loop on the E protein. The Fab therefore defines a new (non-overlapping) site on E.

name:	iedb
homePage:	http://www.iedb.org

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