Humanized monoclonal antibodies derived from chimpanzee Fabs protect against Japanese encephalitis virus in vitro and in vivo.

Title:

Humanized monoclonal antibodies derived from chimpanzee Fabs protect against Japanese encephalitis virus in vitro and in vivo.

identifier:	1489897
description:	epitope description:K179 antigen name:Genome polyprotein host organism:Pan troglodytes
aggregation:	instance of dataset
availability:	available
primaryPublications:	18480437

study type:	b cell assays
subject species:	Japanese encephalitis virus

fullName:	Ana P Goncalvez Cheng-Hsin Chien Kamolchanok Tubthong Inna Gorshkova Carrie Roll Olivia Donau Peter Schuck Sutee Yoksan Sy-Dar Wang Robert H Purcell Ching-Juh Lai

method:	in vivo assay

name:	Humanized monoclonal antibodies derived from chimpanzee Fabs protect against Japanese encephalitis virus in vitro and in vivo.
description:	The humanized mAb was adoptively transferred into recipient mice. The mAb protected 100% these mice from lethal challenge with JEV. MAb A3 was also shown to be protective in 3 out of 12 mice when transferred 1 day after viral challenge (separate assay).

name:	iedb
homePage:	http://www.iedb.org

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.