Protection against measles virus encephalitis by monoclonal antibodies binding to a cystine loop domain of the H protein mimicked by peptides which are not recognized by maternal antibodies.

Title:

Protection against measles virus encephalitis by monoclonal antibodies binding to a cystine loop domain of the H protein mimicked by peptides which are not recognized by maternal antibodies.

Dataset

identifier:	1493325
description:	epitope description:CKGKIQALCENPEWA antigen name:Hemagglutinin glycoprotein host organism:Mus musculus BALB/c antibody name:BH6, BH21, BH216
aggregation:	instance of dataset
availability:	available
primaryPublications:	8887481

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1006504
landingPage:	http://www.iedb.org/assay/1493325

Publication

type:	Literature
publicationVenue:	J Gen Virol
dates:	1996

Dimension

study type:	b cell assays
subject species:	Measles morbillivirus

Person

fullName:	D Ziegler P Fournier G A Berbers H Steuer K H Wiesmü ller B Fleckenstein F Schneider G Jung C C King C P Muller

Data Type

method:	biological activity

Study

name:	Protection against measles virus encephalitis by monoclonal antibodies binding to a cystine loop domain of the H protein mimicked by peptides which are not recognized by maternal antibodies.
description:	Only those epitope-specific mAbs generated against native MV (BH6, BH21, BH216) were capable of inhibiting hemagglutinin of monkey erythrocytes. In a separate assay these mAbs were also shown to neutralizing MV in vitro. For optimal binding of mAbs to the epitope, disulphide bonds were required in addition to a linear C-terminal extension.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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