Peptide mimics of the group B meningococcal capsule induce bactericidal and protective antibodies after immunization.

Title:

Peptide mimics of the group B meningococcal capsule induce bactericidal and protective antibodies after immunization.

identifier:	1493371
description:	epitope description:PPWDFDAGEGIH host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	17371999

study type:	b cell assays
subject species:

fullName:	Carla Lo Passo Angela Romeo Ida Pernice Paolo Donato Angelina Midiri Giuseppe Mancuso Milena Arigò Carmelo Biondo Roberta Galbo Salvatore Papasergi Franco Felici Giuseppe Teti Concetta Beninati

method:	biological activity

name:	Peptide mimics of the group B meningococcal capsule induce bactericidal and protective antibodies after immunization.
description:	There was no detectable bactericidal acitivity in the sera of mice immunized with the two plasmids containing a secretory signal peptide before epitope with or without a Th epitope. Mice immunized with plasmids expressing the epitope or the epitope preceded by a Th epitope had moderate serum bactericidal acitvity; Adding a plasmid containing IFN-g gene increased the number of responding animals.

name:	iedb
homePage:	http://www.iedb.org

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