The latex allergen hev B 5 is an antigen with repetitive murine B-cell epitopes. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

The latex allergen hev B 5 is an antigen with repetitive murine B-cell epitopes.

Dataset

identifier:	1494405
description:	epitope description:PAEGEK antigen name:Hev b 5 host organism:Mus musculus BALB/c antibody name:3G3, 6A10, 6F6
aggregation:	instance of dataset
availability:	available
primaryPublications:	15241001

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1012857
landingPage:	http://www.iedb.org/assay/1494405

Publication

type:	Literature
publicationVenue:	Int Arch Allergy Immunol
dates:	2004

Dimension

study type:	b cell assays
subject species:	Hevea brasiliensis

Person

fullName:	Donald H Beezhold Vicky L Hickey Michael F Sutherland Robyn E O'Hehir

Data Type

method:	antigen inhibition

Study

name:	The latex allergen hev B 5 is an antigen with repetitive murine B-cell epitopes.
description:	The epitope-specific mAbs bound to natural latex protein. MAbs 6A10 and 3G3 were IgG1, and 6F6 was IgG2b. Mutant Hev b 5 with the Glu substituted with a Met led to significantly less binding with the mAb, and competitive ELISA were similarly less effective. Other epitopes that the mAbs recognized were APETEK and PAEEEK (the dominant epitope), also in Hev b 5.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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