A conjugate vaccine composed of a heat shock protein 60 T-cell epitope peptide (p458) and Neisseria meningitidis type B capsular polysaccharide.

Title:

A conjugate vaccine composed of a heat shock protein 60 T-cell epitope peptide (p458) and Neisseria meningitidis type B capsular polysaccharide.

identifier:	1494413
description:	epitope description:NEDQKIGIEIIKRALKI antigen name:60 kDa heat shock protein, mitochondrial host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	16843573

study type:	b cell assays
subject species:	Mus musculus

fullName:	Hila Amir-Kroll Luis Riveron Maria E Sarmiento Gustavo Sierra Armando Acosta Irun R Cohen

method:	ELISA

name:	A conjugate vaccine composed of a heat shock protein 60 T-cell epitope peptide (p458) and Neisseria meningitidis type B capsular polysaccharide.
description:	Low doses of the epitope coupled to Meningococcal type B capsular polysaccharide (MnB) is more effective to induce IgG Abs to Meningococcal type B capsular polysaccharide (MnB), and three immunizations are required to induce response. The most of isotypes is IgG1, low levels of the IgG2a, IgG2b, IgG3 and IgM isotypes were observed. Meningococcal type B capsular polysaccharide (MnB)-p458 induced long -lasting Ab to Meningococcal type B capsular polysaccharide (MnB). But Meningococcal type B capsular polysaccharide (MnB) + p458 or MnB alone couldn't. PBS is an effective vehicle to induce anti-MnB Abs, adjuvant is unnecessary. There is no interference between Meningococcal type B capsular polysaccharide (MnB)-p458 and Meningococcal type C capsular polysaccharide (MnC)-p458 conjugated vaccines.

name:	iedb
homePage:	http://www.iedb.org

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.