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Title: Exploring computational lead optimisation with affinity constants obtained by surface plasmon resonance for the interaction of PorA epitope peptides with antibody against Neisseria meningitidis.
identifier: 1494434
description:
epitope description:DTNNN
antigen name:Major outer membrane protein P.IA
host organism:Mus musculus
antibody name:MN12H2
aggregation:
instance of dataset
availability:
available
primaryPublications: 11786227
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1008758
landingPage: http://www.iedb.org/assay/1494434
type:
Literature
publicationVenue:
Biochim Biophys Acta
dates:
2001
study type: b cell assays
subject species: Neisseria meningitidis serogroup B
fullName:
M J Fischer
C Kuipers
R P Hofkes
L J Hofmeyer
E E Moret
N J de Mol
method:
surface plasmon resonance (SPR)
name:
Exploring computational lead optimisation with affinity constants obtained by surface plasmon resonance for the interaction of PorA epitope peptides with antibody against Neisseria meningitidis.
description:
Epitope-specifc mAb recognized peptide GTXDTNNL (X= Norleucine) in surface plasmon resonance. Peptides with a mutation at epitopic residue N5 all showed a lower affinity.

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