Construction of hevein (Hev b 6.02) with reduced allergenicity for immunotherapy of latex allergy by comutation of six amino acid residues on the conformational IgE epitopes.

Title:

Construction of hevein (Hev b 6.02) with reduced allergenicity for immunotherapy of latex allergy by comutation of six amino acid residues on the conformational IgE epitopes.

Dataset

identifier:	1494618
description:	epitope description:R5, K10, E29, Y30, H35, Q38 antigen name:Hev b 6 host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	14764736

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1012976
landingPage:	http://www.iedb.org/assay/1494618

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	2004

Dimension

study type:	b cell assays
subject species:	Hevea brasiliensis

Person

fullName:	Piia Karisola Jari Mikkola Nisse Kalkkinen Kari J Airenne Olli H Laitinen Susanna Repo Olli T Pentikä inen Timo Reunala Kristiina Turjanmaa Mark S Johnson Timo Palosuo Markku S Kulomaa Harri Alenius

Data Type

method:	antigen inhibition

Study

name:	Construction of hevein (Hev b 6.02) with reduced allergenicity for immunotherapy of latex allergy by comutation of six amino acid residues on the conformational IgE epitopes.
description:	Competition ELISA confirmed that mutant Hev with the 6 epitopic residues mutated was much less effective at inhibiting binding of patient IgE to Hev.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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