Antibodies targeting linear determinants of the envelope protein protect mice against West Nile virus.

Title:

Antibodies targeting linear determinants of the envelope protein protect mice against West Nile virus.

identifier:	1499955
description:	epitope description:VCRQGVVDRGWGNGCGLFGK antigen name:Genome polyprotein host organism:Equus caballus
aggregation:	instance of dataset
availability:	available
primaryPublications:	18190253

study type:	b cell assays
subject species:	West Nile virus strain 2741

fullName:	Michel Ledizet Kalipada Kar Harald G Foellmer Nathalie Bonafé Karen G Anthony L Hannah Gould Sandra L Bushmich Erol Fikrig Raymond A Koski

method:	ELISA

name:	Antibodies targeting linear determinants of the envelope protein protect mice against West Nile virus.
description:	The reference positions correspond to the Envelope protein region of the viral polyprotein. This sequence corresponds to the fusion loop region. The author provided GenBank identifier was GI: 7717201. IgGs were affinity-purified to the epitope from anti-WNV truncated E protein sera, and its ability to cross-react to the the homologous domain from Dengue virus type 1 was analyzed. Considering the reactivity to the immunogen as 100%, the cross-reactive level of recognition was 44%.

name:	iedb
homePage:	http://www.iedb.org

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