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Title: Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation.
identifier: 1497451
description:
epitope description:THGQWNKPSK
antigen name:Major prion protein
host organism:Mus musculus PrP null
antibody name:P
aggregation:
instance of dataset
availability:
available
primaryPublications: 16962610
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1013075
landingPage: http://www.iedb.org/assay/1497451
type:
Literature
publicationVenue:
J Mol Biol
dates:
2006
study type: b cell assays
subject species: Bos taurus
fullName:
Bé
atrice Luginbü
hl
Zoltan Kanyo
R Mark Jones
Robert J Fletterick
Stanley B Prusiner
Fred E Cohen
R Anthony Williamson
Dennis R Burton
Andreas Plü
ckthun
method:
x-ray crystallography
name:
Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation.
description:
The crystal structure of P Fab in complex with the epitope, BoPrP (95–104), was determined.

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