DNA vaccines expressing B and T cell epitopes can protect mice from FMDV infection in the absence of specific humoral responses.

Title:

DNA vaccines expressing B and T cell epitopes can protect mice from FMDV infection in the absence of specific humoral responses.

identifier:	1498386
description:	epitope description:TTTYTASARGDLAHLTTTHARHLP antigen name:Polyprotein host organism:Mus musculus Swiss
aggregation:	instance of dataset
availability:	available
primaryPublications:	16563575

study type:	b cell assays
subject species:	Foot-and-mouth disease virus C-S8c1

fullName:	Belen Borrego Paloma Fernandez-Pacheco Llilianne Ganges Nieves Domenech Natalia Fernandez-Borges Francisco Sobrino Fernando Rodrí guez

method:	in vivo assay

name:	DNA vaccines expressing B and T cell epitopes can protect mice from FMDV infection in the absence of specific humoral responses.
description:	The epitope sequence is from the reference cited: Toja et al. (1999) Virus Res 64: 161-171 [PMID: 10518172]. Two of 4 outbred Swiss ICR-CD1 mice immunized with the epitope did not develop viremia 48 h after challenge with 10³ pfu FMDV. Only one of the protected mice had developed virus neutralizing antibodies.

name:	iedb
homePage:	http://www.iedb.org

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.