Characterization of neutralizing monoclonal antibody escape mutants of Hantaan virus 76118. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Characterization of neutralizing monoclonal antibody escape mutants of Hantaan virus 76118.

Dataset

identifier:	1498955
description:	epitope description:I515 antigen name:Hantaan orthohantavirus protein host organism:Mus musculus BALB/c antibody name:11E10
aggregation:	instance of dataset
availability:	available
primaryPublications:	9505967

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1011486
landingPage:	http://www.iedb.org/assay/1498955

Publication

type:	Literature
publicationVenue:	Arch Virol
dates:	1998

Dimension

study type:	b cell assays
subject species:	Hantaan virus 76-118

Person

fullName:	M Kikuchi K Yoshimatsu J Arikawa R Yoshida Y C Yoo Y Isegawa K Yamanishi S I Azuma

Data Type

method:	biological activity

Study

name:	Characterization of neutralizing monoclonal antibody escape mutants of Hantaan virus 76118.
description:	Neutralization escape mutants were selected by the monoclonal antibody and sequenced in order to reveal the amino acid mutation (residue 515 I to T). In further experiments, the escape mutant virus showed a significant decrease in virulence in suckling mice.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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