A malaria vaccine candidate based on a hepatitis B virus core platform. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

A malaria vaccine candidate based on a hepatitis B virus core platform.

Dataset

identifier:	1499160
description:	epitope description:NANPNANPNANP antigen name:Circumsporozoite (CS) protein host organism:Mus musculus B10 X B10.S antibody name:Mouse sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	12602355

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1012181
landingPage:	http://www.iedb.org/assay/1499160

Publication

type:	Literature
publicationVenue:	Intervirology
dates:	2002

Dimension

study type:	b cell assays
subject species:	Plasmodium falciparum

Person

fullName:	Matti Sä llberg Janice Hughes Joyce Jones Tom R Phillips David R Milich

Data Type

method:	immuno staining

Study

name:	A malaria vaccine candidate based on a hepatitis B virus core platform.
description:	Mice immunized with the HBcAg-CSP hybrid containing the NANP, NVDP and CSP 326-345 epitopes responded with high anti-sporozoite IFAT antibody titer to the epitope. Separate assays demonstrated that the NVDP epitope significantly enhanced titers (2-3 orders of magnitude) compared to NANP alone or NANP plus CSP (326-345). The C-terminal Cys (C342) of the CSP (326-345) epitope is critical for the stability and therefore immunogenicity of the immunogen complex.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.