Antigenic sites of poliovirus type 3 eliciting IgA monoclonal antibodies in orally immunized mice.

Title:

Antigenic sites of poliovirus type 3 eliciting IgA monoclonal antibodies in orally immunized mice.

identifier:	1499995
description:	epitope description:D417 antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:1B8
aggregation:	instance of dataset
availability:	available
primaryPublications:	11277698

study type:	b cell assays
subject species:	Human poliovirus 3 strain Sabin

fullName:	G Buttinelli F M Ruggeri J Marturano F Novello V Donati L Fiore

method:	biological activity

name:	Antigenic sites of poliovirus type 3 eliciting IgA monoclonal antibodies in orally immunized mice.
description:	The epitopic residue recognized by mAb 1B8 was determined by sequencing neutralization-resistant virus variants selected with mAbs. MAb 1B8 did not neutralize a variant with mutation D77N in the VP3 protein. The mAb also neutralized the Leon type 3 wild poliovirus, but did not cross-neutralize Sabin type 1 or 2 poliovirus.

name:	iedb
homePage:	http://www.iedb.org

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