Immunological Data Discovery Index
Immunological Data Discovery Index
| Title: | Antigenic sites of poliovirus type 3 eliciting IgA monoclonal antibodies in orally immunized mice. |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1013053 |
| landingPage: |
http://www.iedb.org/assay/1499998 |
| type: |
Literature
|
| publicationVenue: |
Virology
|
| dates: |
2001
|
| study type: | b cell assays |
| subject species: | Human poliovirus 3 strain Sabin |
| fullName: |
G Buttinelli
F M Ruggeri
J Marturano
F Novello
V Donati
L Fiore
|
| method: |
biological activity
|
| name: |
Antigenic sites of poliovirus type 3 eliciting IgA monoclonal antibodies in orally immunized mice.
|
| description: |
The epitopic residues recognized by mAbs 1F5, 1F9, 1G1, 2B5, and 3B9 were determined by sequencing neutralization-resistant virus variants selected with the mAbs. MAbs 1F5, 1F9, 1G1, 2B5, and 3B9 did not neutralize variants with mutation L236F in the VP3 protein or R286S or N288D in the VP1 protein. The mAbs also neutralized the Leon type 3 wild poliovirus, but did not cross-neutralize Sabin type 1 or 2 poliovirus.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |