Roles of adjuvant and route of vaccination in antibody response and protection engendered by a synthetic matrix protein 2-based influenza A virus vaccine in the mouse.

Title:

Roles of adjuvant and route of vaccination in antibody response and protection engendered by a synthetic matrix protein 2-based influenza A virus vaccine in the mouse.

Dataset

identifier:	1500758
description:	epitope description:SLLTEVETPIRNEWGSRSNDSSDP host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	17974006

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1007833
landingPage:	http://www.iedb.org/assay/1500758

Publication

type:	Literature
publicationVenue:	Virol J
dates:	2007

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Krystyna Mozdzanowska Darya Zharikova Mare Cudic Laszlo Otvos Walter Gerhard

Data Type

method:	in vivo assay

Study

name:	Roles of adjuvant and route of vaccination in antibody response and protection engendered by a synthetic matrix protein 2-based influenza A virus vaccine in the mouse.
description:	One day after passive transfer of the epitope-specific mAb, mice were exposed to respiratory tract challenge with 4 LD50 of PR8 influenza virus and monitored for weight loss and survival. The IgG2a switch variant of the mAb provided total protection from death and less weight loss, while the IgG2b and IgG1 isotype variants of the mAb were less protective.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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