Molecular and structural analysis of immunoglobulin E-binding epitopes of Pen ch 13, an alkaline serine protease major allergen from Penicillium chrysogenum.

Title:

Molecular and structural analysis of immunoglobulin E-binding epitopes of Pen ch 13, an alkaline serine protease major allergen from Penicillium chrysogenum.

Dataset

identifier:	1501566
description:	epitope description:TAGEGIVIYGVDTGIDIGHADFGGRAEWGTN antigen name:Pen ch 13 host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	15663570

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/461
landingPage:	http://www.iedb.org/assay/1501566

Publication

type:	Literature
publicationVenue:	Clin Exp Allergy
dates:	2004

Dimension

study type:	b cell assays
subject species:	Penicillium chrysogenum

Person

fullName:	H-Y Lai M F Tam H Chou S-S Lee H-Y Tai H-D Shen

Data Type

method:	phage display

Study

name:	Molecular and structural analysis of immunoglobulin E-binding epitopes of Pen ch 13, an alkaline serine protease major allergen from Penicillium chrysogenum.
description:	The epitope sequence is from the reference cited: Chou et al. (2002) Int. Arch. Allergy Immunol. 127: 15-26 [PMID: 11893850]. Fine mapping of IgE epitopes using overlapping 9-mer peptides, identified the epitope as GHADFGGR. Single and double amino acid substitution showed that residues His and Phe at positions 19 and 22, respectively, were important for antibody binding to Pen ch 13.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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