Molecular and structural analysis of immunoglobulin E-binding epitopes of Pen ch 13, an alkaline serine protease major allergen from Penicillium chrysogenum.

Title:

Molecular and structural analysis of immunoglobulin E-binding epitopes of Pen ch 13, an alkaline serine protease major allergen from Penicillium chrysogenum.

Dataset

identifier:	1501573
description:	epitope description:QDASNSSPASAPNVCTIAASTNSDGSASFTNFGSVVDLY antigen name:Pen ch 13 host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	15663570

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/461
landingPage:	http://www.iedb.org/assay/1501573

Publication

type:	Literature
publicationVenue:	Clin Exp Allergy
dates:	2004

Dimension

study type:	b cell assays
subject species:	Penicillium chrysogenum

Person

fullName:	H-Y Lai M F Tam H Chou S-S Lee H-Y Tai H-D Shen

Data Type

method:	phage display

Study

name:	Molecular and structural analysis of immunoglobulin E-binding epitopes of Pen ch 13, an alkaline serine protease major allergen from Penicillium chrysogenum.
description:	The epitope sequence is from the reference cited: Chou et al. (2002) Int. Arch. Allergy Immunol. 127: 15-26 [PMID: 11893850]. Fine mapping of IgE epitopes using overlapping 9-mer peptides, identified the epitope as SFTNFGSVV. Amino acid substitutions of Val and Asp at positions 36 and 37, respectively, and deletion of Tyr at position 39 reduced the binding of patients' serum IgE to the mutant Pen ch 13 protein.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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