Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1013221 |
| landingPage: |
http://www.iedb.org/assay/1502302 |
| type: |
Literature
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| publicationVenue: |
Cancer Immunol Immunother
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| dates: |
2008
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| study type: | b cell assays |
| subject species: | Hepatitis C virus (isolate 1) |
| fullName: |
Darja Kanduc
Luciana Tessitore
Guglielmo Lucchese
Anthony Kusalik
Emanuel Farber
Francesco M Marincola
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| method: |
ELISA
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| name: |
Sequence uniqueness and sequence variability as modulating factors of human anti-HCV humoral immune response.
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| description: |
This peptide corresponds to the NS2 region of the polyprotein. This peptide has a low similarity level in comparison with the human proteome
only one occurrence of a match for all the possible 5-mers contained in this peptide is found in the human proteome. The peptide is poorly conserved in other HCV subtypes: Two substitutions in subtype 1a (isolate H), five and six substitutions in subtype 2a strain JFH-1 and HC-J6, respectively, four susbtitutions in subtype 1b (strains Taiwan, BK, Con1, Japanese and HC-JT), and six substitutions in subtype 2b (strains HC-J8 and JPUT971017).
Partially purified antibodies from sera of HCV patients who had not yet received therapeutic treatments were analyzed.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
