Construction and functional activities of chimeric mouse-human immunoglobulin G and immunoglobulin M antibodies against the Neisseria meningitidis PorA P1.7 and P1.16 epitopes.

Title:

Construction and functional activities of chimeric mouse-human immunoglobulin G and immunoglobulin M antibodies against the Neisseria meningitidis PorA P1.7 and P1.16 epitopes.

Dataset

identifier:	1503007
description:	epitope description:DTNNN antigen name:Major outer membrane protein P.IA host organism:Mus musculus antibody name:151,F-9; 184,F-12
aggregation:	instance of dataset
availability:	available
primaryPublications:	14500492

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1009928
landingPage:	http://www.iedb.org/assay/1503007

Publication

type:	Literature
publicationVenue:	Infect Immun
dates:	2003

Dimension

study type:	b cell assays
subject species:	Neisseria meningitidis serogroup B H44/76

Person

fullName:	Terje E Michaelsen Ø istein Ihle Karen Johanne Beckstrø m Tove K Herstad Jan Kolberg E Arne Hø iby Audun Aase

Data Type

method:	biological activity

Study

name:	Construction and functional activities of chimeric mouse-human immunoglobulin G and immunoglobulin M antibodies against the Neisseria meningitidis PorA P1.7 and P1.16 epitopes.
description:	The epitope-specific chimeric mAbs 151,F-9 and 184,F-12 induced a respiratory bust (RB) associated with opsonophagocytosis of meningococcal strain H44/76. A lower response was observed with IgG1 and IgM.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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